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DIN (Drug Identification Number)
02480824 Cabometyx 20 mg Tablet
02480832 Cabometyx 40 mg Tablet
02480840 Cabometyx 60 mg Tablet
How does this medication work? What will it do for me?
Cabozantinib belongs to the group of cancer-fighting medications known as antineoplastics and more specifically to a class of medications called tyrosine kinase inhibitors. This medication works by blocking signals that allow cancer cells to grow and divide and it also helps to block the growth of new blood vessels in the area of the tumour. New blood vessels help the cancer to grow and spread. Cabozantinib is used to treat a type of advanced kidney cancer called renal cell carcinoma for people who have previously been treated with a specific type of cancer medication.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each yellow, film-coated, round tablet with no score, debossed with "XL" on one side and "20 " on the other side of the tablet, contains 20 mg of cabozantinib as cabozantinib (S)-maleate. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl cellulose, hypromellose 2910, iron oxide yellow, lactose anhydrous, magnesium stearate, microcrystalline cellulose, titanium dioxide and triacetin.
Each yellow, film-coated, triangle tablet with no score, debossed with "XL" on one side and "40" on the other side of the tablet, contains 40 mg of cabozantinib as cabozantinib (S)-maleate. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl cellulose, hypromellose 2910, iron oxide yellow, lactose anhydrous, magnesium stearate, microcrystalline cellulose, titanium dioxide and triacetin.
Each yellow, film-coated, oval tablet with no score, debossed with "XL" on one side and "60" on the other side of the tablet, contains 60 mg of cabozantinib as cabozantinib (S)-maleate. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl cellulose, hypromellose 2910, iron oxide yellow, lactose anhydrous, magnesium stearate, microcrystalline cellulose, titanium dioxide and triacetin.
How should I use this medication?
The recommended dose of cabozantinib is 60 mg taken by mouth, once daily. This medication needs to be taken on an empty stomach. Take it one hour before eating or two hours after eating. Swallow the tablets whole. Do not chew or crush the tablets.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor.
If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 12 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not take this medication if you are allergic to cabozantinib or any ingredients of the medication.
What side effects are possible with this medication?
- changed sense of taste
- decreased appetite
- dry skin
- hand-foot skin reaction (e.g., redness, blisters, and pain on the palms of hands or soles of feet)
- mouth sores or mouth pain
- muscle spasms
- pain in arms, legs, and joints
- signs of electrolyte imbalance (e.g., muscle pain or cramps, weakness, irregular heartbeat, lack of coordination, thirst, confusion)
- stomach pain
- weight loss
- difficulty speaking
- jaw pain
- high blood pressure (e.g., headache, vision changes, nausea, vomiting)
- rash or skin redness
- shortness of breath
- signs of a blood clot in the arm or leg (tenderness, pain, swelling, warmth, or redness in the arm or leg) or lungs (chest pain, coughing up blood, shortness of breath)
- signs of fluid build-up around the lungs (e.g., chest pain, cough, hiccups, rapid breathing)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- signs of low blood calcium levels (e.g., muscle spasms, tingling or numbness of the fingers and mouth, twitching, or memory loss)
- symptoms of a fistula (e.g., anal bleeding, pain with bowel movements, fever, chills, foul smelling discharge from the anus)
- symptoms of irregular heartbeat (e.g., chest pain; dizziness; rapid, pounding heartbeat; shortness of breath)
- wounds that do not heal
- signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
- signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
- signs of reversible posterior leukoencephalopathy syndrome (e.g., headache, seizures, weakness, confusion, high blood pressure, vision changes, difficulty thinking clearly)
- symptoms of severely increased blood pressure: (e.g., chest pain, blurred vision, dizziness, excessive tiredness, headache, stronger or faster heartbeat)
- symptoms of blood clot in the lungs (difficulty breathing, sharp chest pain that is worse when breathing in, coughing, coughing up blood, sweating, or passing out)
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Abnormal heart rhythms: Cabozantinib may cause a heart rhythm problem called QT prolongation. If you have a history of QT prolongation, slow or irregular heartbeat, irregular heart rhythm, heart failure, heart attack, heart disease, taking other medications known to cause QT prolongation, or a family history of sudden cardiac death at less than 50 years of age, discuss with your doctor how this medication may affect your medical condition, or how your medical condition may affect the dosing and effectiveness of this medication. Your doctor will perform tests at regular intervals to monitor for any changes in your heart rhythm.
Birth control: If you or your partner is of childbearing age, it is important that you use effective birth control, to avoid possible harm to the baby. Birth control should be used while taking cabozantinib and for at least 4 months after the last dose. If you become pregnant while taking this medication, contact your doctor immediately.
Bleeding: Cabozantinib may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. If you have a history of severe bleeding, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Blood clots: This medication may increase the chance of blood clot formation, causing reduction of blood flow to organs or the extremities.
If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as heart attack, stroke, or clots in the deep veins of your leg or lungs. Discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you experience symptoms such as sharp pain and swelling in the leg, difficulty breathing, chest pain, blurred vision or difficulty speaking, contact your doctor immediately.
Decreased heart rate: This medication can cause decreased heart rate. If you have a low heart rate or experience symptoms of a low heart rate, such as fatigue, dizziness, or confusion contact your doctor.
Drowsiness/reduced alertness: Cabozantinib may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by this medication.
Gastrointestinal perforation and fistula: Cabozantinib has been reported to cause perforations (holes) and fistulas (abnormal connections) in the stomach or intestines. People who have medical conditions affecting the stomach or bowel, such as Crohn's disease or diverticulitis, or previous stomach surgeries may be more likely to experience a tear in the lining of the stomach, which can cause serious bleeding. This can occur without abdominal pain.
If you notice bloody or black and tarry stools, or vomit blood or material that looks like coffee grounds, seek medical help immediately.
Grapefruit juice: Grapefruit and grapefruit juice affect how cabozantinib is removed from the body. Consuming grapefruit products can cause too much of the medication to build up in the body and cause possibly harmful side effects. People should not drink grapefruit juice or eat grapefruit at anytime while taking this medication for treatment.
High blood pressure: Cabozantinib can cause blood pressure to increase; possibly to a life-threatening level. If you have high blood pressure, it should be well controlled before starting to take cabozantinib. If your blood pressure is not controlled while taking cabozantinib, your doctor may have you stop taking this medication. If you have high blood pressure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Infection: As well as killing cancer cells, cabozantinib can reduce the number of cells that fight infection in the body (white blood cells).
If possible, avoid contact with people with contagious infections. Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness.
Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. Cabozantinib may also reduce liver function and can cause liver failure. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Reversible Posterior Leukoencephalopathy Syndrome (RPLS): This is a rare disease of the brain that may occur when using medications like cabozantinib. If you experience signs and symptoms of RPLS, such as headache, seizures, change in awareness or consciousness or vision changes, contact your doctor immediately.
Surgery: This medication can cause wounds to take longer to heal. If you have surgery scheduled, including dental surgery, it may be necessary to stop taking this medication for 28 days before the surgery. Make sure all members of your health care team are aware that you are taking cabozantinib and talk to your doctor about whether you should stop this medication before surgery.
Thyroid Disease: This medication may cause decreased thyroid gland function. If you have problems with your thyroid gland, cabozantinb may make these problems worse. If you experience symptoms of underactive thyroid, such as unexpectedly feeling cold, depression, constipation or fatigue, let your doctor know. If you have a history of thyroid disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: The use of cabozantinib may cause harm to the developing baby if it is taken by the mother during pregnancy. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if cabozantinib passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Breast-feeding should be avoided while taking cabozantinib and for 4 months after the last dose of medication. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
What other drugs could interact with this medication?
- antiarrythmics (e.g., amiodarone, disopyramide, dofetilide, dronedarone, procainamide, quinidine, sotalol)
- "azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole)
- bisphosphonates (e.g., alendronate, etidronate, risedronate)
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- grapefruit juice
- HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
- HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
- macrolide antibiotics (e.g., clarithromycin, erythromycin)
- other protein kinase inhibitors (e.g., crizotinib, dasatinib, imatinib, nilotinib)
- St. John's wort
- seizure medications (e.g., carbamazepine, phenytoin, phnoebarbital, primidone)
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
There may be an interaction between cabozantinib and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2019. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Cabometyx
All material © 1996-2019 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
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